Spotlight Poster Discussion 6 – Wednesday, December 8, 2021: 5:00 pm – 6:30 pm CT
   
  Genomic and genetic analysis on metastases
PD6-02 The metastatic breast cancer project - Expanding the clinical, genomic, and transcriptomic landscape of metastatic breast cancer through patient-partnered research
Jain E, Kim D, Gomez Tejeda Zanudo J, Balch S, McGillicuddy M, Tomson BN, Hernandez TG, Thomas BS, Abravanel DL, Shah S, Ramos R, Sosa D, Small I, Sterlin L, Winnicki S, Nguyen C, Dunphy M, Anastasio E, Golub TR, Painter CA, Wagle N. Broad Institute, Cambridge, MA; Dana Farber Cancer Institute, Boston, MA.
PD6-03 Spatio-molecular dissection of the breast cancer metastatic microenvironment
Abravanel DL, Klughammer J, Blosser T, Goltsev Y, Jiang S, Bai Y, Murray E, Alon S, Cui Y, Goodwin DR, Sinha A, Cohen O, Slyper M, Ashenberg O, Dionne D, Jané-Valbuena J, Porter CBM, Segerstolpe A, Waldman J, Vigneau S, Helvie K, Frangieh A, DelloStritto L, Patel M, We J, Pfaff K, Cullen N, Lako A, Turner M, Wakiro I, Napolitano S, Kanodia A, Ortiz R, MacKichan C, Inga S, Chen J, Thorner AR, Rotem A, Rodig S, Chen F, Boyden ES, Nolan GP, Zhuang X, Rozenblatt-Rosen O, Johnson BE, Regev A, Wagle N. Dana-Farber Cancer Institute, Boston, MA; Broad Institute of MIT and Harvard, Cambridge, MA; Harvard University, Cambridge, MA; Stanford University, Stanford, CA; Massachusetts Institute of Technology, Cambridge, MA; Massachusetts Institute of Technology, Howard Hughes Medical Institute, Cambridge, MA; Harvard University, Howard Hughes Medical Institute, Cambridge, MA.
PD6-04 Mutational landscape and immune infiltration of breast cancer metastases to gynecologic and other organs
Louie AD, Chudasama R, Wu S, Capelletti M, Magee D, Korn WM, Kaklamani V, Tan AR, Chalasani P, El-Deiry WS, Dizon D, Graff SL. Brown University, Providence, RI; Caris Life Sciences, Phoenix, AZ; UT Health San Antonio, MD Anderson Cancer Center, San Antonio, TX; Levine Cancer Institute, University of North Carolina, Charlotte, NC; University of Arizona, Tucson, AZ.
PD6-05 Characterization of the immune landscape of primary vs metastatic breast cancer in a real-world data cohort
Chhibber A, Van Naarden Braun K, Han C, Chang H, Roberts M, Li B. Bristol Myers Squibb, Lawrence Township, NJ.
PD6-06 Comprehensive characterization of neurotransmitters and neuronal signaling gene alterations in invasive breast cancers
Kang I, Deshpande K, Persing S, Yin J, Xiu J, Korn WM, Zeng J, Roussos-Torres ET, Lu J, Spicer D, Sener SF, Tan AR, Sumrall A, Hoon DSB, Ma CX, Anders CK, McArthur HL, Basho R, Lenz H-J, Neman J. University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, CA; University of Southern California, Los Angeles, CA; Caris Life Sciences, Phoenix, AZ; University of California, San Francisco, San Francisco, CA; Los Angeles County and USC (LAC+USC) Medical Center, Los Angeles, CA; Levine Cancer Institute, Charlotte, NC; John Wayne Cancer Institute, Los Angeles, CA; Washington University School of Medicine, St. Louis, MO; Duke University, Durham, NC; Cedars-Sinai Medical Center, Los Angeles, CA.
PD6-07 Whole genome sequencing-based circulating tumor DNA profiling of metastatic breast cancer patients for molecular characterization and therapy response prediction
Sohn J, Kim MH, Ahn JM, Ryu W-J, Kim S-G, Kim JH, Kim TY, Han HJ, Kim JY, Park HS, Park S, Park BW, Kim SI, Cho EH, Kim GM. Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea; Green Cross Genome, Yongin-si, Republic of Korea; Avison Biomedical Research Center, Yonsei University College of Medicine, Seoul, Republic of Korea; Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
PD6-08 Exploring the interplay among ESR1/PIK3CA codon variants, oncogenic pathway alterations and clinical phenotype of metastatic breast cancer (MBC) through circulating tumor DNA (ctDNA) next-generation sequencing (NGS)
Gerratana L, Davis AA, Velimirovic M, Clifton K, Hensing WL, Shah AN, Dai CS, Reduzzi C, D’Amico P, Zhang Q, Wehbe F, Wander S, Gradishar WJ, Behdad A, Puglisi F, Ma CX, Bardia A, Cristofanilli M. Northwestern University, Chicago, IL; Washington University in St. Louis, St. Louis, MO; Massachusetts General Hospital, Boston, MA; CRO Aviano National Cancer Institute, Aviano, Italy; Massimo Cristofanilli, Chicago, IL.