Schedule at a Glance

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Monday, 12/9/19
12:00 pm - 5:00 pm	REGISTRATION - Main Lobby
Tuesday, 12/10/19
8:00 am - 7:00 pm	REGISTRATION - Main Lobby

11:45 am - 1:30 pm	WORKSHOPS
	Molecular Biology in Breast Oncology - Hemisfair Ballroom - 3rd Level Moderator: Carlos L. Arteaga, MD UT Southwestern Medical Center Simmons Comprehensive Cancer Center Dallas, TX Antibody-drug conjugates in cancer: Principles for synthesis and preclinical development Gail Lewis Phillips Genentech, Inc. South San Francisco, CA Defining a cancer dependency map William C. Hahn, MD, PhD Dana-Farber Cancer Institute Boston, MA Approaches to targeting the anti-apoptotic machinery in breast cancer Geoffrey Lindeman, MBBS, FRACP, PhD The Walter & Eliza Hall Institute of Medical Research Parkville, AUSTRALIA Novel target discovery by longitudinal deep spatial & molecular analysis of breast cancers Joe Gray, PhD Oregon Health & Science University Portland, OR

	Developing Novel Therapeutics in the Metastatic Setting - Stars at Night Ballroom 3&4 - 3rd Level Moderator: Virginia G. Kaklamani, MD UT Health San Antonio San Antonio, TX Window versus neoadjuvant trial - choose wisely Alastair M. Thompson, BSc (Hons), MB ChB, MD, FRCSEd Baylor College of Medicine Houston, TX Therapeutic development in the era of precision medicine: Paradigm shift from maximum tolerated dose (MTD) to optimal biological dose (OBD) Aditya Bardia, MD, MPH Massachusetts General Hospital Harvard Medical School Boston, MA Design and analysis of window and neoadjuvant trials Meredith Regan, ScD Dana-Farber Cancer Institute Harvard Medical School Boston, MA How to talk to patients about participating in clinical trials Patricia Spears, BSc UNC Lineberger Comprehensive Cancer Center Chapel Hill, NC

1:30 pm - 2:00 pm	BREAK

2:00 pm - 7:00 pm	EDUCATIONAL SESSIONS - Stars at Night Ballrooms 1, 2, 3&4 and Hemisfair Ballroom - 3rd Level Updates on advances in key areas and in technologies available for translational research. Many of these sessions will provide attendees with a better understanding of the background leading up to talks they will hear in the succeeding days, and some of the techniques that will be used. These presentations should also provide researchers with ideas and techniques to be considered for their own studies.

2:00 pm - 3:30 pm	Twenty Years of Targeting HER2: Where Are We Now? – Hemisfair Ballroom - 3rd Level Moderator: Mothaffar F. Rimawi, MD Baylor College of Medicine Houston, TX What is a HER2-positive in breast cancer in 2018? Stuart J. Schnitt, MD Brigham and Women's Hospital Dana-Farber Cancer Institute Boston, MA Early HER2-positive breast cancer: Doing more and less Lisa A. Carey, MD UNC - Lineberger Comprehensive Cancer Center Chapel Hill, NC Advanced HER2-positive breast cancer: Overcoming treatment resistance Mothaffar F. Rimawi, MD Baylor College of Medicine Houston, TX Insights and Controversies in Metastasis Biology - Stars at Night Ballroom 1 - 3rd Level Moderator: Michael Lewis, PhD Baylor College of Medicine Houston, TX The EMT and metastasis controversy: Where things stand in 2018 Heide L. Ford, PhD University of Colorado School of Medicine Aurora, CO Breast cancer's metastatic moment: How postpartum tissue involution facilitates progression Pepper J. Schedin, PhD Oregon Health and Science University Portland, OR Exosome-mediated stimulation of metastasis Andy J. Minn, MD University of Pennsylvania Philadelphia, PA Contemporary Management of Breast Cancer Brain Metastases – Stars at Night Ballroom 2&3 - 3rd Level Moderator: Nancy U. Lin, MD Dana-Farber Cancer Institute Harvard Medical School Boston, MA Brain metastases of breast cancer Patricia S. Steeg, PhD National Cancer Institute Bethesda, MD Multidisciplinary management of breast cancer brain metastases Christina I. Tsien, MD Washington University St. Louis, MO Systemic therapy for breast cancer brain metastases Nancy U. Lin, MD Dana-Farber Cancer Institute Boston, MA Partial Breast Irradiation - Where Does it Stand? ‐ Stars at Night Ballroom 4 - 3rd Level Moderator: Richard Crownover, MD, PhD UT Health San Antonio San Antonio, TX Partial breast irradiation: Efficacy and patient selection Charlotte Coles, MB ChB, MRCP, FRCR, PhD University of Cambridge Cambridge, UNITED KINGDOM Treatment morbidity and quality of life considerations Timothy J. Whelan, BSc, BM, BCh, MSc, FRCPC McMaster University Hamilton, CANADA Techniques and technical considerations Frank A. Vicini, MD, FACR, FABS, FASTRO MHP Radiation Oncology Institute Farmington Hills, MI

3:45 pm - 5:15 pm	Late Recurrence in ER Positive Breast Cancer: Therapeutic Interventions and Biological Insights – Hemisfair Ballroom - 3rd Level Moderator: Matthew J. Ellis, MD, PhD Baylor College of Medicine Houston, TX Tumor dormancy and recurrence Lewis A. Chodosh, MD, PhD Perelman School of Medicine University of Pennsylvania Philadelphia, PA Clinical and molecular profiles to identify who is at risk? Mitchell Dowsett, PhD Ralph Lauren Centre for Breast Cancer Research London, UNITED KINGDOM Late recurrence in ER-positive breast cancer Julie R. Gralow, MD University of Washington Seattle, WA Metabolic Reprogramming in Breast Cancer – Stars at Night Ballroom 1 - 3rd Level Moderator: Alexander Bishop, DPhil, BSc Greehey Children's Cancer Research Institute UT Health San Antonio San Antonio, TX Oxidative stress responses in cancer Joan S. Brugge, PhD Harvard Medical School Boston, MA PI3K in breast cancer, glutamine changes and methionine addiction Alex Toker, PhD Beth Israel Deaconess Medical Center Boston, MA Systems approaches to attacking cancer vulnerabilities defined by metabolic, de-differentiation and genomic instability states Thomas G. Graeber, PhD University of California Los Angeles Los Angeles, CA Management of the Axilla after Neoadjuvant Therapy: Beyond the Clinical Trials – Stars at Night Ballroom 2&3 - 3rd Level Moderator: Monica Morrow, MD Memorial Sloan Kettering Cancer Center New York, NY Methods to minimize the false negative rate of sentinel lymph node surgery after neoadjuvant chemotherapy for node positive breast cancer Judy C. Boughey, MD Mayo Clinic Rochester, MN Practical approach to the axilla after neoadjuvant chemotherapy: What the clinical trials don't address Andrea V. Barrio, MD Memorial Sloan Kettering Cancer Center New York, NY Indications for radiation treatments after neoadjuvant chemotherapy while awaiting the results of clinical trials Thomas A. Buchholz, MD Scripps Health San Diego, CA Exposures Throughout the Lifecourse - New Data on The Environment, Hormones, and Alcohol - Stars at Night Ballroom 4 - 3rd Level Moderator: Melissa L. Bondy, PhD Baylor College of Medicine Houston, TX Windows of susceptibility across the lifecourse and breast cancer Lawrence H. Kushi, ScD Kaiser Permanente Northern California Oakland, CA New data on hormones and risk of breast cancer Susan E. Hankinson, ScD University of Massachusetts Amherst, MA Does breast cancer prevention need an 18th amendment? New evidence on alcohol and breast cancer Mary Beth Terry, PhD Columbia University New York, NY

5:30 pm - 7:00 pm	Updates in the Treatment of Triple Negative Breast Cancer - Hemisfair Ballroom - 3rd Level Moderator: Virginia G. Kaklamani, MD UT Health San Antonio San Antonio, TX Optimizing treatment of early stage triple negative breast cancer: Clinical challenges and new scientific horizons Angela DeMichele, MD, MSCE Abramson Cancer Center University of Pennsylvania Philadelphia, PA Updates on immunotherapy for TNBC Sylvia Adams, MD New York University New York, NY Triple negative breast cancer: Current and future directions in metastatic patients Jenny C. Chang, MD Houston Methodist Hospital Houston, TX Translational Insights in Estrogen Receptor Signaling and Endocrine Resistance - Bench to Bedside – Stars at Night Ballroom 1 - 3rd Level Moderator: Rachel Schiff, PhD Baylor College of Medicine Houston, TX Recurrent ESR1 mutations activating mutations in breast cancer Rinath M. Jeselsohn, MD Dana-Farber Cancer Institute Boston, MA Mining noncoding mutations for drivers of development in ER alpha-positive breast cancer Mathieu Lupien, PhD Princess Margaret Cancer Centre Toronto, CANADA Blockade of estrogen signaling boosts antitumor immunity by inhibiting tumor-induced pathological myelopoiesis Jose Conejo-Garcia, MD, PhD H. Lee Moffitt Cancer Center Tampa, FL Managing Lymphedema in 2018: Can We Forgo the Sleeve?- Stars at Night Ballroom 2&3 - 3rd Level Moderator: Bhuvaneswari Ramaswamy, MBBS, MRCP Ohio State University Columbus, OH Lymphedema management in 2018: Are we making any progress? Babak J. Mehrara, MD Memorial Sloan Kettering Cancer Center New York, NY Current status of diagnosis, monitoring, and non-surgical management of lymphedema Sarah A. McLaughlin, MD Mayo Clinic Jacksonville, FL Microsurgical treatment of lymphedema David W. Chang, MD, FACS University of Chicago Chicago, IL BRCA 1/2: Beyond DNA Repair - Stars at Night Ballroom 4 - 3rd Level Moderator: Ratna K. Vadlamudi, PhD UT Health San Antonio San Antonio, TX Linking cancer pathogenesis to emerging functions of the BRCA proteins beyond DNA repair Ashok Venkitaraman, MBBS, PhD MRC Cancer Unit University of Cambridge Cambridge, UNITED KINGDOM Link between BRCA1 and Pol II pausing in mammary gland development and tumorigenesis Rong Li, PhD The George Washington University Washington, DC BRCA1/2/3 and p53 in replication fork stability Katharina Schlacher, PhD UT MD Anderson Cancer Center Houston, TX

7:30 pm - 10:00 pm	OPEN SATELLITE EVENT presented by Research to Practice - Marriott Rivercenter
	Addressing Current Questions and Controversies in the Management of Early and Advanced Breast Cancer For more information and to register for this event, please click on the link below: http://www.researchtopractice.com/Meetings/SA2018
Wednesday, 12/11/19
7:00 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 8:00 am	CONTINENTAL BREAKFAST - Hall 2

8:00 am - 8:15 am	WELCOME AND OPENING REMARKS - Hall 3 Virginia G. Kaklamani, MD UT Health San Antonio San Antonio, TX

8:15 am - 8:45 am	PLENARY LECTURE 1 - Hall 3
	Breast Tumor Evolution and Intratumor Heterogeneity - Insights from Single Cell Genomics Nicholas E. Navin, PhD UT MD Anderson Cancer Center Houston, TX
8:45 am - 11:15 am	GENERAL SESSION 1 - Hall 3

10:45 am - 5:00 pm	EXHIBITS - Exhibit Hall 2

11:15 am - 12:00 pm	WILLIAM L. MCGUIRE MEMORIAL LECTURE – Hall 3
	Hold That Scalpel! Using the Tumor to Determine the Treatment Ian E. Smith, MD, FRCP, FRCPE The Royal Marsden NHS Foundation Trust London, UNITED KINGDOM

12:00 pm - 1:00 pm	BREAK

12:00 pm - 1:00 pm	CAREER DEVELOPMENT FORUM - Room 304

1:00 pm - 2:00 pm	CLINICAL SCIENCE FORUM - Stars at Night Ballroom 1&2 - 3rd Level
	Cancer Genetics: Updates for Breast Cancer Care Moderator: Judy E. Garber, MD, MPH Dana-Farber Cancer Institute Boston, MA Polygenic risk scores for breast cancer: Ready or not? D. Gareth Evans, FRCP, MD, MBBS University of Manchester Manchester, UNITED KINGDOM Breast cancer genetic testing and results in diverse populations Allison W. Kurian, MD, MSc Stanford University School of Medicine Stanford, CA Moderate penetrance mutations: What to do? Susan M. Domchek, MD University of Pennsylvania Philadelphia, PA
1:00 pm - 2:00 pm	BASIC SCIENCE FORUM 1 - Stars at Night Ballroom 3&4 - 3rd Level
	Peering into Tumor-Microenvironment Interaction in Metastasis Moderator: Yi Li, PhD Baylor College of Medicine Houston, TX High resolution intravital imaging of the mechanism of how breast cancer initiates and sustains systemic dissemination John S. Condeelis, PhD Albert Einstein College of Medicine Bronx, NY Neutrophil extracellular traps promote breast cancer metastasis Mikala Egeblad, PhD Cold Spring Harbor Laboratory Cold Spring Harbor, NY New insights into early-stage bone colonization of disseminated breast cancer cells Xiang Zhang, PhD Baylor College of Medicine Houston, TX

2:15 pm - 3:15 pm	SUSAN G. KOMEN® BRINKER AWARDS FOR SCIENTIFIC DISTINCTION LECTURES - Hall 3
	SUSAN G. KOMEN® BRINKER AWARD FOR SCIENTIFIC DISTINCTION IN BASIC SCIENCE Modeling Immune Response: Lessons Learned from Mouse Models of Cancer Development Lisa Coussens, PhD Oregon Health & Sciences University Portland, OR
	SUSAN G. KOMEN® BRINKER AWARD FOR SCIENTIFIC DISTINCTION IN CLINICAL RESEARCH The Challenge of Doing Less Eric P. Winer, MD Dana-Farber Cancer Institute Boston, MA

3:15 pm - 5:00 pm	GENERAL SESSION 2 - Hall 3

5:00 pm - 7:00 pm	Spotlight Session 1: Developmental Therapeutics - Stars at Night Ballroom 1&2 - 3rd Level

5:00 pm - 7:00 pm	Spotlight Session 2: Biomarkers in Clinical Trials - Stars at Night Ballroom 3&4 - 3rd Level

5:00 pm - 7:00 pm	POSTER SESSION 1 & Reception - Hall 1

7:30 pm - 9:30 pm	OPEN SATELLITE EVENT hosted by Clinical Care Options - Marriott Rivercenter
	Advances in HR+/HER2- Breast Cancer: Current Practice, Open Questions, and Future Directions For more information and to register for this event, please click on the link below: https://events.clinicaloptions.com/oncology/programs/program/?id=74197947-cfa7-e811-80de-005056943d50

7:30 pm - 10:00 pm	OPEN SATELLITE EVENT hosted by Prime Oncology - Marriott Riverenter
	Triple-Negative Breast Cancer - Developing a More Positive Approach For more information and to register for this event, please click on the link below: www.prIMEoncology.org/triple-negative-breast-cancer-san-antonio-2018
Thursday, 12/12/19
6:45 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 9:00 am	Spotlight Session 3: Next Steps in HER2+ Targeted Therapy - Stars at Night Ballroom 1&2 - 3rd Level

7:00 am - 9:00 am	Spotlight Session 4: Breast Cancer Screening and Imaging - Stars at Night Ballroom 3&4 - 3rd Level

7:00 am - 9:00 am	POSTER SESSION 2 & continental breakfast - Hall 1

9:00 am - 9:30 am	PLENARY LECTURE 2 - Hall 3
	Neoadjuvant Endocrine Therapy: The Times They are A-Changing Ingrid A. Mayer, MD, MSCI Vanderbilt University Medical Center Nashville, TN

9:30 am - 11:30 am	GENERAL SESSION 3 - Hall 3

10:45 am - 5:00 pm	Exhibits - Hall 2

11:30 am - 12:00 pm	AACR DISTINGUISHED LECTURESHIP IN BREAST CANCER RESEARCH - Hall 3
	What Can we Learn from Breast Cancers that Metastasize or Don't? Zena Werb, PhD University of California San Francisco San Francisco, CA
12:00 pm - 1:00 pm	BREAK

12:00 pm - 1:00 pm	CAREER DEVELOPMENT FORUM - Room 304

1:00 pm - 2:00 pm	CASE DISCUSSION 1 - Stars at Night Ballroom 1&2 - 3rd Level Moderator: Mothaffar Rimawi, MD Baylor College of Medicine Houston, TX

1:00 pm - 2:00 pm	TRANSLATIONAL SCIENCE FORUM 2 - Stars at Night Ballroom 3&4 - 3rd Level
	PI3K Pathway in Breast Cancer Moderator: Carlos L. Arteaga, MD UT Southwestern Simmons Comprehensive Cancer Center Dallas, TX The complexity of targeting PI3K for cancer therapy Lewis C. Cantley, PhD The Sandra and Edward Meyer Cancer Center New York, NY Clinical development of inhibitors of the PI3K pathway Cristina Saura Manich, MD, PhD Vall d'Hebron University Hospital Barcelona, SPAIN Lessons learned from the development of PI3K inhibitors in metastatic breast cancer Dejan Juric, MD Massachusetts General Hospital Boston, MA

2:15 PM - 3:15 pm	MINI-SYMPOSIUM 1 - Hall 3
	Man vs. Machine: Now and in the Future Moderator: Jenny C. Chang, MD Houston Methodist Hospital Houston, TX Deep learning systems for reading mammograms and breast tomosynthesis Nico Karssemeijer, PhD Radboud University Medical Centre Nijmegen, NETHERLANDS Artificial intelligence to optimize the accuracy and predictiveness of breast cancer pathology Andrew H. Beck, MD, PhD PathAI Cambridge, MA

3:15 pm - 5:00 pm	GENERAL SESSION 4 - Hall 3

5:00 pm - 7:00 pm	Spotlight Session 5: Immunotherapy - Stars at Night Ballroom 1&2 - 3rd Level

5:00 pm - 7:00 pm	Spotlight Session 6: QOL, Survivorship, and Cost of Care - Stars at Night Ballroom 3&4 - 3rd Level

5:00 pm - 7:00 pm	POSTER SESSION 3 & Reception - Hall 1

7:30 pm - 10:00 pm	OPEN SATELLITE EVENT presented by Medscape Education - Marriott Rivercenter
	Debates, Dilemmas, and Consensus: Evolving Standards of Care in HER2- Positive Breast Cancer For more information and to register for this event, please click on the link below: https://www.medscape.org/symposium/her2-positive-breast-cancer-registration

7:30 pm - 10:00 pm	OPEN SATELLITE EVENT presented by Clinical Care Options - Marriott Rivercenter
	PARP Inhibitors in Breast Cancer: Expert Perspectives on Clinical Application and Genetic Testing For more information and to register for this event, please click on the link below: https://events.clinicaloptions.com/oncology/programs/program/?id=022097b6-21aa-e811-80de-005056943d50
Friday, 12/13/19
6:45 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 9:00 am	Spotlight Session 7: Biology of Invasive Lobular and Endocrine Resistant Breast Cancer - Stars at Night Ballroom 1&2 - 3rd Level

7:00 am - 9:00 am	Spotlight Session 8: What's New in Loco-Regional Therapy - Stars at Night Ballroom 3&4 - 3rd Level

7:00 am - 9:00 am	POSTER SESSION 4 & continental breakfast - Hall 1

9:00 am - 9:45 am	DEBATE - Hall 3
	Should All Women with Breast Cancer and Positive Lymph Nodes Receive Chemotherapy? Chairman: Clifford A. Hudis, MD American Society of Clinical Oncology Alexandria, VA Daniel Hayes, MD, FASCO, FACP University of Michigan Ann Arbor, MI Harold Burstein, MD, PhD Dana-Farber Cancer Institute Boston, MA

9:45 am - 11:30 am	GENERAL SESSION 5 - Hall 3

10:45 am - 5:00 pm	EXHIBITS - Hall 2

11:30 am- 12:00 pm	2018 AACR OUTSTANDING INVESTIGATOR AWARD IN BREAST CANCER RESEARCH, SUPPORTED BY THE BREAST CANCER RESEARCH FOUNDATION - Hall 3
	Breast Cancer in Young Women: Understanding Differences to Improve Outcomes Ann Partridge, MD, MPH Dana-Farber Cancer Institute Boston, MA

12:00 pm - 1:00 pm	BREAK

12:00 pm - 1:00 pm	NETWORKING WITH THE EXPERTS - Hall 2

1:00 pm- 2:00 pm	CASE DISCUSSION 2 - Stars at Night Ballroom 1&2 - 3rd Level Moderator: Mothaffar Rimawi, MD Baylor College of Medicine Houston, TX

1:00 pm - 2:00 pm	TRANSLATIONAL SCIENCE FORUM 3 – Stars at Night Ballroom 3&4 - 3rd Level
	Interplay Between Breast Cancer Targeted Therapies and the Immune System Moderator: C. Kent Osborne, MD Baylor College of Medicine Houston, TX Beyond B cells: Targeting BCL-2 pro-survival proteins in breast cancer Geoffrey Lindeman, MBBS, FRACP, PhD Walter and Eliza Hall Institute of Medical Research Parkville, AUSTRALIA Modulation of anti-tumor immunity using CDK4/6 inhibitors Shom Goel, B Med Sci, MBBS, FRACP, PhD Dana-Farber Cancer Institute Boston, MA

2:15 pm - 3:15 pm	MINI-SYMPOSIUM 2 - Hall 3
	Over and Under Treatment: Getting It Right for Each Patient Moderator: Eric P. Winer, MD Dana-Farber Cancer Institute Boston, MA Overtreatment: First, do no harm Reshma Jagsi, MD, DPhil University of Michigan Ann Arbor, MI Missed opportunities - The perils of under-treatment Rachel A. Freedman, MD, MPH Dana-Farber Cancer Institute Boston, MA

3:15 pm - 5:00 pm	GENERAL SESSION 6 - Hall 3

5:00 pm - 7:00 pm	Spotlight Session 9: Metastasis/microenvironment - Stars at Night Ballroom 1&2 - 3rd Level

5:00 pm - 7:00 pm	POSTER SESSION 5 & Reception - Hall 1

6:00 pm - 7:30 pm	SPECIAL SESSION - Stars at Night Ballroom 3&4 - 3rd Level
	View from the Trenches: What Will You Do On Monday Morning? Moderator: Eric P. Winer, MD Dana-Farber Cancer Institute Boston, MA Panel Members: Matthew P. Goetz, MD Mayo Clinic Rochester, MN Monica Morrow, MD Memorial Sloan Kettering Cancer Center New York, NY Debra Patt, MD, MPH Texas Oncology Austin, TX Meredith M. Regan, ScD Dana-Farber Cancer Institute Boston, MA Hope S. Rugo, MD UCSF Helen Dilller Family Comprehensive Cancer Center San Francisco, CA Bárbara Segarra-Vázquez, DHSc University of Puerto Rico San Juan, PR
Saturday, 12/14/19
6:45 am - 9:00 am	Registration - Main Lobby

7:00 am - 9:00 am	POSTER SESSION 6 & continental breakfast - Hall 1

9:00 am - 11:00 am	The Year in Review - Hall 3
	Moderator: C. Kent Osborne, MD Baylor College of Medicine Houston, TX Basic science Alana L. Welm, PhD University of Utah Huntsman Cancer Institute Salt Lake City, UT Translational research Geoffrey Lindeman, MBBS, FRACP, PhD The Walter & Eliza Hall Institute of Medical Research Parkville, AUSTRALIA Early breast cancer Masakazu Toi, MD, PhD Kyoto University Kyoto, JAPAN Metastatic breast cancer Sara Hurvitz, MD University of California, Los Angeles Los Angeles, CA

11:00 am	Adjournment


12:00 pm - 1:45 pm

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