Schedule at a Glance

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Schedule at a Glance

Daily Schedule:

Poster Sessions:

Spotlight Sessions:

Schedule at a Glance

Tuesday, 12/5/17
8:00 am - 7:00 pm	REGISTRATION - Main Lobby

11:00 am - 12:45 pm	INTERNATIONAL SESSION Global View of Value Based Medicine - Hemisfair Ballroom 2&3 - 3rd Level Moderator: Peggy Porter, MD Fred Hutchinson Cancer Research Center Seattle, WA Health system responses to women's cancers in the Americas: Closing divides to achieve universal health coverage Felicia M. Knaul, PhD University of Miami Miami, FL The challenge of definition and adoption; perspective from the Middle East Sana Al Sukhun, MD, MSc Jordanian Oncology Society Amman, JORDAN Breast imaging in resource constrained regions: Lessons from Uganda Constance D. Lehman, MD, PhD Massachusetts General Hospital Boston, MA

11:00 am - 12:45 pm	WORKSHOPS Molecular Biology in Breast Oncology - Stars at Night Ballroom 1&2 - 3rd Level Moderator: Carlos L. Arteaga, MD Vanderbilt University Medical Center Vanderbilt-Ingram Cancer Center Nashville, TN Drug target discovery: how to go about it? Markus Warmuth, MD H3 Biomedicine Cambridge, MA Bench-based approaches to discover mechanisms of drug resistance (i.e. CRISPR, genome library screens, etc.) Nikhil Wagle, MD Dana-Farber Cancer Institute Boston, MA Genomics & bioinformatics (big data) in breast cancer research Mia Levy, MD, PhD Vanderbilt University Medical Center Nashville, TN Single cell genomics and tumor heterogeneity Jorge S. Reis-Filho, MD, PhD Memorial Sloan Kettering Cancer Center New York, NY

11:00 am - 12:45 pm	Methods in Breast Cancer Clinical Research - Stars at Night Ballroom 3&4 - 3rd Level Moderator: Virginia G. Kaklamani, MD UT Health San Antonio San Antonio, TX Novel statistical clinical trial designs Yu Shyr, PhD Vanderbilt Ingram Cancer Center Nashville, TN Incorporating biomarkers in clinical trials Edith Perez, MD Genentech South San Francisco, CA What about neoadjuvant trials and path CR Hope Rugo, MD University of California San Francisco, CA Regulatory issues Tatiana M. Prowell, MD FDA/Johns Hopkins Silver Spring, MD

12:45 pm - 1:00 pm	BREAK

1:00 pm - 6:00 pm	EDUCATIONAL SESSIONS - Stars at Night Ballrooms 1&2, 3&4 and Hemisfair Ballroom 2&3 - 3rd Level Updates on advances in key areas and in technologies available for translational research. Many of these sessions will provide attendees with a better understanding of the background leading up to talks they will hear in the succeeding days, and some of the techniques that will be used. These presentations should also provide researchers with ideas and techniques to be considered for their own studies.

1:00 pm - 2:30 pm	Shifting Paradigms in Radiation Oncology – Hemisfair Ballroom 2&3 - 3rd Level Moderator: Richard L. Crownover, MD, PhD UT Health San Antonio San Antonio, TX Accelerated partial breast irradiation: Update of an ASTRO consensus guideline Candace R. Correa, MD Community Cancer Center Normal, IL Guidelines for postmastectomy radiotherapy Abram Recht, MD, FASTRO, FASCO Beth Israel Deaconess Medical Center Boston, MA Advanced technologies to optimize outcomes and minimize toxicities Reshma Jagsi, MD, DPhil University of Michigan Ann Arbor, MI Changing Recommendations for Intermediate Risk Lesions – Stars at Night Ballroom 1&2 - 3rd Level Moderator: Virginia G. Kaklamani, MD UT Health San Antonio San Antonio, TX The pathology of high risk proliferative lesions of the breast Kalliopi P. Siziopikou, MD, PhD Northwestern University Chicago, IL Clinical management of women with increased breast cancer risk based on histologic lesions Amy C. Degnim, MD Mayo Clinic Rochester, MN Managing increased breast cancer risk based on high and moderate penetrance gene mutations Judy E. Garber, MD, MPH Dana-Farber Cancer Institute Boston, MA Beyond Expression Profiling: RNA Epigenetics – Stars at Night Ballroom 3&4 - 3rd Level Moderator: Douglas Yee, MD University of Minnesota Minneapolis, MN Drugging protein synthesis in cancer therapy Robert J. Schneider, PhD New York University New York, NY Targeting RNA splicing in cancer therapy Stephan Vagner, PhD Institut Curie-Centre de Recherche Orsay, FRANCE Progress, paradigms, and pathways of long non-coding RNAs in cancer Liuqing Yang, PhD UT MD Anderson Cancer Center Houston, TX

2:45 pm - 4:15 pm	Medical Treatment of HER2+++ Breast Cancer – Hemisfair Ballroom 2&3 - 3rd Level Moderator: Angelo Di Leo, MD, PhD Hospital of Prato Prato, ITALY HER2 testing - 2017 guidelines for HER2 testing Robert B. Jenkins, MD, PhD Mayo Clinic Rochester, MN Adjuvant therapy for HER2-positive breast cancers: Is less more? Ruth M. O'Regan, MD University of Wisconsin Madison, WI Can we improve treatment tailoring in advanced HER2+ breast cancer? Martine J. Piccart, MD, PhD Institut Jules Bordet Brussels, BELGIUM Multi-Level Influences on Breast Cancer Disparities – Stars at Night Ballroom 1&2 - 3rd Level Moderator: Melissa L. Bondy, PhD Baylor College of Medicine Houston, TX Place as a cause of breast cancer disparities in Appalachia Electra D. Paskett, BS, MSPH, PhD Ohio State University Columbus, OH Biologic, cultural and health systems influences on breast cancer disparities in Latinas Amelie G. Ramirez, DrPH UT Health San Antonio San Antonio, TX Biologic and health system determinants of breast cancer disparities in African Americans Katherine E. Reeder-Hayes, MD University of North Carolina Chapel Hill, NC Panel Discussion The Breast Tumor Microenvironment: A Target for Therapy – Stars at Night Ballroom 3&4 - 3rd Level Moderator: Leisha A. Emens, MD, PhD Johns Hopkins University Baltimore, MD How tumor metabolism contributes to the immunosuppressive microenvironment Jeffrey C. Rathmell, PhD Vanderbilt University Nashville, TN Do tumors overcome immune surveillance by blocking dendritic cell development David G. DeNardo, PhD Washington University School of Medicine St. Louis, MO Opportunities for immune therapy and prevention Robert H. Vonderheide, MD, DPhil University of Pennsylvania Philadelphia, PA

4:30 pm - 6:00 pm	Management Controversies in Locoregional Recurrence - Hemisfair Ballroom 2&3 - 3rd Level Moderator: Irene Wapnir, MD Stanford Women's Cancer Center Stanford, CA Challenges in the management of locoregional recurrence Monica Morrow, MD Memorial Sloan Kettering Cancer Center New York, NY Local regional recurrence Richard C. Zellars, MD Indiana University Indianapolis, IN Should all patients with locoregional recurrence receive systemic therapy? William J. Gradishar, MD Northwestern University Chicago, IL Circulating Tumor Cells and Liquid Biopsies, Translation to Clinical Practice – Stars at Night Ballroom 1&2 - 3rd Level Moderator: Matthew J. Ellis, MD, PhD Baylor College of Medicine Houston, TX Liquid biopsies in breast cancer - challenges and opportunities Sarah-Jane Dawson, MBBS (Hons), FRACP, PhD (Cantab) Peter MacCallum Cancer Centre Melbourne, AUSTRALIA Exosome analysis in breast cancer: Clinical translation Jacqueline F. Bromberg, MD, PhD Memorial Sloan Kettering Cancer Center New York, NY Circulating complexes of stromal and tumor cells in breast cancer metastasis Dorraya El-Ashry, PhD University of Minnesota Minneapolis, MN Androgen, Progesterone and Glucocorticoid Receptors: Drivers of Breast Tumor Progression or Reprogramming of Steroid Receptors During Breast Tumor Progression - Stars at Night Ballroom 3&4 - 3rd Level Moderator: Suzanne A.W. Fuqua, PhD Baylor College of Medicine Houston, TX Androgen receptor in breast cancer. When might it serve as a suitable target? Jennifer K. Richer, PhD University of Colorado Aurora, CO Tracking progesterone receptor actions in breast cancer progression: Jekyll and Hyde Carol A. Lange, PhD University of Minnesota Minneapolis, MN Modulating glucocorticoid receptor function in breast cancer Suzanne D. Conzen, MD University of Chicago Chicago, IL

6:00 pm - 8:00 pm	RECEPTION

8:00 pm - 10:00 pm	OPEN SATELLITE EVENT hosted by Dr. Neil Love and Research to Practice - Marriott Rivercenter DATA + PERSPECTIVES: Clinical Investigators Explore the Emerging Role of PARP Inhibition in the Management of Breast Cancer For more information and to register for this event, please click on the link below: http://www.researchtopractice.com/Meetings/PARP2017
Wednesday, 12/6/17
7:00 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 8:00 am	CONTINENTAL BREAKFAST - Hall 2

8:00 am - 8:30 am	WELCOME AND OPENING REMARKS - Hall 3 C. Kent Osborne, MD Baylor College of Medicine Houston, TX

8:30 am - 9:00 am	SABCS 40th Anniversary Award Lecture: Past and Future of Cancer Drug Development Richard Pazdur, MD US Food and Drug Administration Silver Spring, MD

9:00 am - 9:30 am	PLENARY LECTURE 1 - Hall 3 Potential of Radiation Therapy to Convert the Tumor into an In Situ Vaccine Silvia C. Formenti, MD Weill Cornell Medicine New York, NY
9:30 am - 11:15 am	GENERAL SESSION 1 - Hall 3

11:00 am - 5:00 pm	EXHIBITS - Exhibit Hall 2

11:15 am - 12:00 pm	WILLIAM L. MCGUIRE MEMORIAL LECTURE – Hall 3 The Early Breast Cancer Trialists' Collaborative Group Sir Richard Peto, FRS University of Oxford Oxford, UNITED KINGDOM

12:00 pm - 1:00 pm	BREAK

1:00 pm - 2:00 pm	CLINICAL SCIENCE FORUM - Stars at Night Ballroom 1&2 - 3rd Level Controversies in the Adjuvant Treatment of ER+ Breast Cancer Moderator: Matthew P. Goetz, MD Mayo Clinic Rochester, MN Adjuvant endocrine therapy for premenopausal ER+ breast cancer Prudence A. Francis, MBBS, B Med Sc, FRACP, MD Peter MacCallum Cancer Centre Melbourne, AUSTRALIA Searching for the optimal duration of adjuvant endocrine therapy in breast cancer Vered Stearns, MD Johns Hopkins University Baltimore, MD

1:00 pm - 2:00 pm	BASIC SCIENCE FORUM 1 - Stars at Night Ballroom 3&4 - 3rd Level Targeting the Tumor Immune Microenvironment Moderator: Xiang Zhang, PhD Baylor College of Medicine Houston, TX Epigenetic therapy activates type 1 interferon signaling to reduce immunosuppression and tumor burden Cynthia A. Zahnow, PhD Johns Hopkins University Baltimore, MD Myeloid-derived suppressor cells: many facets of regulation of tumor progression Dmitry I. Gabrilovich, MD, PhD The Wistar Institute Philadelphia, PA

1:00 pm - 2:00 pm	EDUCATIONAL SESSION - Hemisfair Ballroom 2&3 - 3rd Level Ex-vivo Modeling of Breast Cancer Moderator: Carlos L. Arteaga, MD Vanderbilt University Medical Center Vanderbilt-Ingram Cancer Center Nashville, TN A novel human derived organoid platform for breast cancer research Oded Kopper, PhD Hubrecht Institute Utrecht, NETHERLANDS Breast cancer patient-derived xenografts as models for metastatic progression and therapeutic response Alana L. Welm, PhD University of Utah Salt Lake City, UT Genetic dissection of cancer development, therapy response, and resistance in mouse models of breast cancer Jos Jonkers, PhD Netherlands Cancer Institute Amsterdam, NETHERLANDS

2:15 pm - 3:15 pm	SUSAN G. KOMEN^®BRINKER AWARDS FOR SCIENTIFIC DISTINCTION LECTURES - Hall 3 SUSAN G. KOMEN^® BRINKER AWARD FOR SCIENTIFIC DISTINCTION IN BASIC SCIENCE The Development of Synthetic Lethal Treatments for Cancer Alan Ashworth, PhD, FRS UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, CA SUSAN G. KOMEN^® BRINKER AWARD FOR SCIENTIFIC DISTINCTION IN CLINICAL RESEARCH Molecular Diversity of Human Breast Cancer: Biologic and Therapeutic Implications Dennis J. Slamon, MD, PhD UCLA Jonsson Comprehensive Cancer Center Los Angeles, CA

3:15 pm - 5:00 pm	GENERAL SESSION 2 - Hall 3

5:00 pm - 7:00 pm	Spotlight on Cancer Predisposition, Somatic Changes, and Genetic Testing - Stars at Night Ballroom 1&2 - 3rd Level

5:00 pm - 7:00 pm	Spotlight on Innovations of SLN Mapping + Imaging - Stars at Night Ballroom 3&4 - 3rd Level

5:00 pm - 7:00 pm	POSTER SESSION 1 & Reception - Hall 1

7:30 pm - 10:00 pm	OPEN SATELLITE EVENT hosted by Dr. Neil Love and Research to Practice - Marriott Rivercenter Cases from the Community: Clinical Investigators Provide Their Perspectives on Emerging Research and Actual Patients with Breast Cancer For more information and to register for this event, please click on the link below: http://www.researchtopractice.com/Meetings/SA2017
Thursday, 12/7/17
6:45 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 9:00 am	Spotlight on Novel Drugs / Predicting Response for HER2+ Breast Cancer - Stars at Night Ballroom 1&2 - 3rd Level

7:00 am - 9:00 am	Spotlight on Endocrine Resistance Mediated by CDK4/6, FGFR, and PI3K - Stars at Night Ballroom 3&4 - 3rd Level

7:00 am - 9:00 am	POSTER SESSION 2 & continental breakfast - Hall 1

9:00 am - 9:30 am	PLENARY LECTURE 2 - Hall 3 Advances in the Understanding of Mutational Signatures in Human Cells Serena Nik-Zainal, MD, PhD The Wellcome Trust Sanger Institute Cambridge, UNITED KINGDOM

9:30 am - 11:30 am	GENERAL SESSION 3 - Hall 3

11:00 am - 5:00 pm	Exhibits - Hall 2

11:30 am - 12:00 pm	AACR DISTINGUISHED LECTURESHIP IN BREAST CANCER RESEARCH - Hall 3 Leveraging Preclinical Models of Breast Cancer Jeffrey M. Rosen, PhD Baylor College of Medicine Houston, TX

12:00 pm - 1:00 pm	BREAK

1:00 pm - 2:00 pm	CASE DISCUSSION 1 - Stars at Night Ballroom 1&2 - 3rd Level Moderator: Mothaffar Rimawi, MD Baylor College of Medicine Houston, TX

1:00 pm - 2:00 pm	BASIC SCIENCE FORUM 2 - Stars at Night Ballroom 3&4 - 3rd Level Mechanisms of Early Dissemination, Dormancy and Metastasis Moderator: Julio A. Aguirre-Ghiso, PhD Mount Sinai School of Medicine New York, NY Oncogenic and microenvironmental signals driving early dissemination, dormancy and metastasis Julio A. Aguirre-Ghiso, PhD Mount Sinai School of Medicine New York, NY The perivascular niche protects dormant disseminated tumor cells from therapy Cyrus M. Ghajar, PhD Fred Hutchinson Cancer Research Center Seattle, WA

1:00 pm - 2:00 pm	EDUCATIONAL SESSION - Hemisfair Ballroom 2&3 - 3rd Level Challenges in Advanced/Metastatic Breast Cancer (ABC) Moderator: Fatima Cardoso, MD Champalimaud Clinical Centre Lisbon, PORTUGAL Introduction: Where there is controversy, let it be guidance Fatima Cardoso, MD Champalimaud Clinical Centre Lisbon, PORTUGAL Luminal ABC: optimal use of all available options? Angela M. DeMichele, MD, MSCE University of Pennsylvania Philadelphia, PA Local therapy of limited disease in ABC: what is the evidence? Seema A. Khan, SM, MB Northwestern University Chicago, IL Novel approaches for selection and monitoring of treatment in advanced and metastatic breast cancer - advantages and limitations Prof. Dr. Carsten Denkert Charite Berlin Berlin, GERMANY Balancing active treatment and palliative care in ABC patients Thomas J. Smith, MD Johns Hopkins Sidney Kimmel Comprehensive Cancer Center Baltimore, MD

2:15 pm - 3:15 pm	MINI-SYMPOSIUM 1 - Hall 3 Molecular Subtypes and Clinical Ramifications of TNBC Moderator: Tiffany A. Traina, MD Memorial Sloan Kettering Cancer Center New York, NY Targeting DNA repair deficiency in triple negative breast cancers (TNBC) with G-quadruplex stabilisers Samuel Aparicio, PhD The University of British Columbia Vancouver, CANADA New clinical approaches for TNBC Melinda Telli, MD Stanford University School of Medicine Stanford, CA

3:15 pm - 5:00 pm	GENERAL SESSION 4 - Hall 3

5:00 pm - 7:00 pm	Spotlight on Endocrine Therapy - Stars at Night Ballroom 1&2 - 3rd Level

5:00 pm - 7:00 pm	Spotlight on Immuno Oncology - Stars at Night Ballroom 3&4 - 3rd Level

5:00 pm - 7:00 pm	POSTER SESSION 3 & Reception - Hall 1
7:30 pm - 10:00 pm	OPEN SATELLITE EVENT presented by Medscape Oncology - Marriott Rivercenter The Promise of PARP Inhibitors in Metastatic Breast Cancer: New Data, New Treatments? For more information and to register for this event, please click on the link below: http://www.medscape.org/sites/townhall/public/gbrca-mbc
7:30 pm - 10:00 pm	OPEN SATELLITE EVENT presented by Prime Oncology - Marriott Rivercenter Hope on the Horizon for Triple Negative Breast Cancer
Friday, 12/8/17
6:45 am - 5:15 pm	REGISTRATION - Main Lobby

7:00 am - 9:00 am	Spotlight on Cost Effectiveness / Male Breast Cancer / Fertility - Stars at Night Ballroom 1&2 - 3rd Level

7:00 am - 9:00 am	Spotlight on Landscape of Mutations in Metastatic Breast Cancer - Stars at Night Ballroom 3&4 - 3rd Level

7:00 am - 9:00 am	POSTER SESSION 4 & continental breakfast - Hall 1

9:00 am - 9:30 am	PLENARY LECTURE 3 - Hall 3 Individualizing Management of the Axillary Nodes Tari A. King, MD Dana-Farber Cancer Institute Boston, MA

9:30 am - 11:30 am	GENERAL SESSION 5 - Hall 3

11:00 am - 5:00 pm	EXHIBITS - Hall 2

11:30 am- 12:00 pm	AACR OUTSTANDING INVESTIGATOR AWARD FOR BREAST CANCER RESEARCH FUNDED BY SUSAN G. KOMEN^® - Hall 3 TBD

12:00 pm - 1:00 pm	BREAK

1:00 pm- 2:00 pm	CASE DISCUSSION 2 - Stars at Night Ballroom 1&2 - 3rd Level Moderator: Mothaffar Rimawi, MD Baylor College of Medicine Houston, TX

1:00 pm - 2:00 pm	BASIC SCIENCE FORUM 3 – Stars at Night Ballroom 3&4 - 3rd Level Intratumoral Heterogeneity: Clinical Implications from Basic Science Moderator: Elaine R. Mardis, PhD Nationwide Children's Hospital Columbus, OH Manifestations and implications of subclonal alterations in metastatic breast cancer Sarat Chandarlapaty, PhD Memorial Sloan Kettering Cancer Center New York, NY Breast cancer intra-tumor heterogeneity and its clinical implications Charles Perou, PhD The University Of North Carolina At Chapel Hill Chapel Hill, NC

1:00 pm - 2:00 pm	DEBATE - Hemisfair Ballroom 2&3 - 3rd Level This house believes that all women diagnosed with metastatic breast cancer should undergo next generation sequencing? Chairman: Eric P. Winer, MD Dana-Farber Cancer Institute Boston, MA Funda Meric-Bernstam, MD UT MD Anderson Cancer Center Houston, TX Fabrice André, MD, PhD Institut Gustave Roussy Villejuif, FRANCE

2:15 pm - 3:15 pm	MINI-SYMPOSIUM 2 - Hall 3 Lobular Breast Cancer - Is it a Different Disease? Moderator: Otto Metzger, MD Dana-Farber Cancer Institute Boston, MA Pathology and genomics of lobular breast carcinomas and their precursors Jorge S. Reis-Filho, MD, PhD Memorial Sloan Kettering Cancer Center New York, NY Understanding the unique biology of ILC Steffi Oesterreich, PhD University of Pittsburgh Pittsburgh, PA Tailoring systemic therapy for patients with lobular breast cancer Marco A. Colleoni, MD European Institute of Oncology Milano, ITALY

3:15 pm - 5:00 pm	GENERAL SESSION 6 - Hall 3

5:00 pm - 7:00 pm	POSTER SESSION 5 & Reception - Hall 1

5:00 pm - 7:00 pm	SPECIAL SESSION View from the Trenches: What Will You Do On Monday Morning? - Stars at Night Ballroom 3&4 - 3rd Level Moderator: Lisa A. Carey, MD University of North Carolina at Chapel Hill Chapel Hill, NC Panel Members: Matthew J. Ellis, MD, PhD Baylor College of Medicine Houston, TX Susan G. Hilsenbeck, PhD Baylor College of Medicine Houston, TX Patricia Spears, BS University of North Carolina Chapel Hill, NC Steven E. Vogl, MD Montefiore Medical Center Bronx, NY Eric P. Winer, MD Dana-Farber Cancer Institute Boston, MA
Saturday, 12/9/17
6:45 am - 9:00 am	Registration - Main Lobby

7:00 am - 9:00 am	POSTER SESSION 6 & continental breakfast - Hall 1

9:00 am - 11:00 am	The Year in Review - Hall 3 Moderator: C. Kent Osborne, MD Baylor College of Medicine Houston, TX Basic science Ramon Parsons, MD, PhD Icahn School of Medicine at Mount Sinai New York, NY Translational research Nicholas C. Turner, PHD, FRCP, BM, MA The Royal Marsden Hospital London, UNITED KINGDOM Early breast cancer in review Antonio C. Wolff, MD, FACP, FASCO Johns Hopkins University Baltimore, MD Advanced and metastatic breast cancer Nancy Lin, MD Dana-Farber Cancer Institute Boston, MA

11:00 am	Adjournment


12:00 pm - 1:45 pm

Symposium Overview 2017 SABCS Past Meetings Best Of SABCS

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