Day 2: Wednesday, 12/7/2022
Tuesday | Wednesday | Thursday | Friday | Saturday
WEDNESDAY, DECEMBER 7, 2022
     
All times are CENTRAL Time
 
7:00 am - 8:15 am CT POSTER SESSION #2 - Hall 1
 
7:00 am - 8:15 am CT  SPOTLIGHT POSTER DISCUSSION SESSION #4 - Hemisfair Ballroom 1&2
Single Cell Approaches for Translational Research and Biomarker Discovery
 
7:00 am - 8:15 am CT  SPOTLIGHT POSTER DISCUSSION SESSION #5 - Stars at Night Ballroom 3&4
Advances in TNBC Biology
 
7:00 am - 8:15 am CT  SPOTLIGHT POSTER DISCUSSION SESSION #6 - Stars at Night Ballroom 1&2
Special Populations: Male Breast Cancer/Geriatrics
 
8:30 am - 9:00 am CT  William L. McGuire Memorial Lecture - Hall 3
Jeffrey Rosen, PhD
Baylor College of Medicine
Houston, TX
 
9:00 am - 9:45 am CT GENERAL SESSION #2 - Hall 3
 
9:00 am - 9:15 am CT  GS2-01:    
9:15 am - 9:30 am CT  GS2-02:  
9:30 am - 9:45 am CT  GS2-03:  
9:45 am - 11:00 am CT  HER2 Low: A Separate Entity Special Session - Hall 3
Chairs: Adam Brufsky, MD, PhD
University of Pittsburgh
Pittsburgh, PA
and
Kalliopi Siziopikou, MD, PhD
Northwestern University
Chicago, IL
 
10:00 am - 5:00 pm CT EXHIBITS - Hall 2  
11:00 am - 12:00 pm CT

MINI-SYMPOSIUM #1 - Hall 3

C. Kent Osborne HER2 and ER Crosstalk: Signaling Mechanisms and Clinical Implications Symposium

Moderators: Carlos Arteaga, MD
UT Southwestern Medical Center
Harold C. Simmons Comprehensive Cancer Center
Dallas, TX
and 
Virginia G. Kaklamani, MD
UT Health San Antonio
San Antonio, TX

Special Guest: C. Kent Osborne, MD
Baylor College of Medicine
Houston, TX

HER2 signaling the ER cistrome
Rinath Jeselsohn, MD
Dana-Farber Center Institute
Boston, MA

Oncogene signal transduction and antiestrogen resistance
Rachel Schiff, PhD
Baylor College of Medicine
Houston, TX

Treatment of ER+/HER2+ breast cancer
Stephen Johnston, MBBS
The Royal Marsden Hospital
London, United Kingdom

 
12:00 pm - 12:30 pm CT  PLENARY LECTURE #1 - Hall 3
Lineage-defined Metabolism of Normal Mammary Cells and Origins of Cancer Metabolic
Rama Khokha, PhD
University Health Network
Toronto, Canada
 
12:30 pm - 1:00 pm CT  AACR DISTINGUISED LECTURESHIP IN BREAST CANCER RESEARCH - Hall 3  
12:30 pm - 1:30 pm CT  CAREER DEVELOPMENT FORUM - Room 304  
  The Career Development Forum provides interactive informational interviews with experts on a variety of topics that are important for the career development of early-career scientists. The session is open to early-career scientists, defined as graduate students, postdoctoral or clinical fellows, or medical students and residents, who are registered attendees of the 2022 SABCS.
Limited to 120 participants; attendance to the in-person Career Roundtables will be on a first-come, first-served basis and with no pre-registration required. Badges are required and will be scanned at door for entry. Boxed lunches will be provided.
Participants will have the opportunity to rotate tables every 20 minutes. Some tables topics will have a more clinical focus, while others will have a more laboratory research focus. The subthemes are denoted in parenthesis after the table topic name.
Roundtable Topics
1. Balancing Research and Clinical Practice (Clinical)
2. Becoming a Successful Clinical Trialist (Clinical)
3. Careers in Industry
4. Careers in Basic Science
5. Careers in Translational Research (Clinical)
6. Careers in Translational Research (Laboratory)
7. Career Transitions
8. Negotiating a Job Offer or Promotion
9. How to Get Involved in & Make Collaborative Research Work for You
10. Time Management to Optimize Productivity and Wellness
11. Building a Support Network for Better Work Life Balance
12. Funding Your Own Research
13. Professional Fulfillment and Burnout Mitigation
14. Challenges and Opportunities for Women in Research
15. Promoting Equity and Inclusion in Your Career and Teams
 
1:00 pm - 2:00 pm CT CLINICAL CASE DISCUSSION SESSION - Stars at Night Ballroom 1&2  
 

Moderator: Mothaffar Rimawi, MD
Baylor College of Medicine
Houston, TX

Panelist:

Michael Gnant, MD, FACS, FEBShon
Medical University of Vienna
Vienna, Austria

Celina Kleer, MD
University of Michigan Medical School
Ann Arbor, MI

Julia Maues
GRASP
Washington, DC

George Sledge, Jr, MD
Stanford University
Stanford, CA

Jonathan Strauss, MD
Northwestern
Chicago, IL

Shaveta Vinayak, MD
University of Washington
Seattle, WA

 
1:00 pm - 2:00 pm  CT

FORUM #1 - Stars at Night Ballroom 3&4
Molecular Aspects of DCIS Progression
Moderator: E. Shelley Hwang, MD, MPH
Duke University
Durham, NC

Tumor stroma in DCIS progression
Robert West, MD, PhD
Stanford University Medical Center
Stanford, CA

Clonal evolution of DCIS to invasion

Jelle Wesseling, MD, PhD
Netherlands Cancer Institute
Amsterdam, Netherlands

Defining clinical risk: How do we tailor therapy

Kimberly J. Van Zee, MS, MD, FACS
Memorial Sloan Kettering Cancer Center
New York, NY

 
2:00 pm - 3:00 pm CT 

CLINICAL CONTROVERSIES - Hall 3
Moderator: Lisa Carey, MD, ScM, FASCO
UNC-Lineberger Comprehensive Cancer Center
Chapel Hill, NC

To clip or not to clip
Abigail Caudle, MD
UT MD Anderson Cancer Center
Houston, TX
and
Viviana E. Galimberti, MD, MPH
European Institute of Oncology
Milan, Italy

Duration of endocrine therapy
Kathryn Ruddy, MD, PhD
Mayo Clinic
Rochester, MN
and
Eleftherios (Terry) Mamounas, MD, MSc
Orlando Health Cancer Institute
Orlando, FL

Post neoadjuvant therapy in TNBC
Heather McArthur, MD, MPH
UT Southwestern
Dallas, TX
and
Susan Domchek, MD
University of Pennsylvania School of Medicine
Philadelphia, PA

 
2:00 pm - 3:00 pm CT

MINI-SYMPOSIUM #2 - Stars at Night Ballroom 1&2
Late Recurrence and Tumor Dormancy
Moderator: Alana Welm, PhD
Masonic Cancer Center
University of Minnesota
Minneapolis, MN

NK cell induced dormancy
Ana Luisa Correia, PhD
Champalimaud Research
Lisboa, Portugal

Extra cellular matrix and dormancy
Javier Bravo-Cordero, PhD
Icahn School of Medicine
New York, NY

Implications for clinical care
Alexandra Thomas, MD, FACP
Wake Forest School of Medicine
Winston, Salem, NC

 
2:00 pm - 3:00 pm CT 

FORUM #2 New Targets and Strategies for Immunotherapy - Stars at Night Ballroom 3&4
Moderator: Justin Balko, PhD
Vanderbilt University Medical Center
Nashville, TN

Activating a collaborative innate-adaptive immune response to control metastasis
Mikala Egeblad, PhD
Cold Spring Harbor Laboratory
Cold Spring Harbor, NY

Neutrophil elastase and anti-tumor effects
Lev Becker, PhD
University of Chicago
Chicago, IL

Immunosuppressive macrophages and PARP inhibitor resistance
Jennifer Guerriero, PhD
Brigham and Women's Hospital
Boston, MA

 
3:00 pm - 5:00 pm CT

EDUCATIONAL SESSION BLOCK #2

EDUCATIONAL SESSION BLOCK #2A - Hemisfair Ballroom 1&2
Digital Health and PROs in Breast Cancer Research and Care
Moderator: Ann H. Partridge, MD, MPH
Dana Farber Institute
Boston, MA

What are PROs and evidence for benefit?
Shoshana Rosenberg, ScD, MPH
Weill Cornell Medicine
New York, NY

How to incorporate PROs into clinical care
Oluwadamilola "Lola" Fayanju, MD, MA, MPHS, FACS
Perelman School of Medicine at the University of Pennsylvania
Philadelphia, PA

Where are we going with digital interventions and PROs
Ines Vaz Luis, PhD
Gustave Roussy
Villejuif, France

Patient Advocate Perspective
Patty Spears, BS
UNC Patient Advocates for Research Council
Chapel Hill, NC

EDUCATIONAL SESSION BLOCK #2B - Stars at Night Ballroom 1&2
Antibody Drug Conjugates: Future Directions and Opportunities
Moderator: Ian E. Krop, MD, PhD
Yale School of Medicine
New Haven, CT

Bioengineering and mechanism of action of ADC
Puja Sapra, PhD
AstraZeneca
New York, NY

ADCs in breast oncology: Present and future
Shanu Modi, MD
Memorial Sloan Kettering Cancer Center
New York, NY

Mechanisms of resistance
Leif Ellison, MD, PhD
Massachusetts General Hospital
Boston, MA

EDUCATIONAL SESSION BLOCK #2C - Stars at Night Ballroom 3&4
Spatial and Single Cell Characterization of Breast Cancer Progression
Moderator: Christina Curtis, PhD, MSc
Stanford University School of Medicine
Stanford, CA

Single cell profiling
Alex Swarbrick, PhD
Garvan Institute of Medical Research
Darlinghurst, Australia

Multiplex spatial proteomic profiling
David Rimm, MD, PhD
Yale University
New Haven, CT

Imaging mass cytometry of breast cancer
Raza Ali, MD, FRCPC, MSc
Cancer Research UK Cambridge Institute
Cambridge, United Kingdom

Beyond the lab: Clinical implications
Christina Curtis, PhD, MSc
Stanford University School of Medicine
Stanford, CA

EDUCATIONAL SESSION BLOCK #2D - Hemisfair Ballroom 3
Breast Cancer and Cardiovascular Toxicity: What an Oncologist Needs to Know
Co-Moderator: Carmen Bergom, MD, PhD
Washington University in St. Louis
St. Louis, MO
Co-Moderator: Susan Dent, MD
Duke
Durham, NC

Beyond anthracyclines and trastuzumab: Cardiotoxicity of new novel agents
Susan Dent, MD
Duke
Durham, NC

Radiation therapy and cardiovascular disease in breast cancer
Carmen Bergom, MD, PhD
Washington University in St. Louis
St. Louis, MO

Cardiovascular toxicity and breast cancer: Detection and prevention strategies
Dinesh Thavendiranathan, MD, MSc
Peter Munk Cardiac Center, Toronto General Hospital, University of Toronto
Toronto, Canada

Cardiac problems secondary to chemotherapy
Alexea Gaffney, MD
Stony Brook Medicine
Stony Brook, NY

 
5:00 pm - 6:15 pm CT POSTER SESSION  #3 - Hall 1  
5:00 pm - 6:15 pm CT SPOTLIGHT POSTER DISCUSSION SESSION #7 - Stars at Night Ballroom 3&4
Brain Metastasis
 
5:00 pm - 6:15 pm CT SPOTLIGHT POSTER DISCUSSION SESSION #8 - Stars at Night Ballroom 1&2
Symptom Management and Associate Toxicities
 
5:00 pm - 6:15 pm CT  SPOTLIGHT POSTER DISCUSSION SESSION #9 - Hemisfair Ballroom 1&2
Immune Landscape and Microenvironments
 
7:00 pm - 10:00 pm CT  OPEN SATELLITE EVENTS - Marriott Rivercenter  
 
Tuesday | Wednesday | Thursday | Friday
 

S1-04.

S1-04.

Phase III study of trastuzumab emtansine (T-DM1) vs trastuzumab as adjuvant therapy in patients with HER2-positive early breast cancer with residual invasive disease after neoadjuvant chemotherapy and HER2-targeted therapy including trastuzumab: primary results from KATHERINE
Limited to 200 participants; registrations will be accepted on a first-come, first-served basis and are free of charge. Badges are required and will be scanned at door for registration.   Attendees should prepare to visit 3-4 tables during the session. Attendees will be asked to rotate tables every 20 minutes.
Limited to 200 participants; registrations will be accepted on a first-come, first-served basis and are free of charge. Badges are required and will be scanned at door for registration.   Attendees should prepare to visit 3-4 tables during the session. Attendees will be asked to rotate tables every 20 minutes.
Limited to 200 participants; registrations will be accepted on a first-come, first-served basis and are free of charge. Badges are required and will be scanned at door for registration.   Attendees should prepare to visit 3-4 tables during the session. Attendees will be asked to rotate tables every 20 minutes.
Tuesday | Wednesday | Thursday | Friday | Saturday