2019 Preliminary Program

PRELIMINARY PROGRAM
Working titles/topics shown. Final titles and speakers will follow
EDUCATIONAL SESSIONS

Tuesday, December 10, 2019

Most of the presentations at SABCS focus on the latest clinical and basic research results relating to breast cancer. By contrast, educational sessions are designed to inform and update those interested in a review on a particular topic. Although these sessions may include new specific research findings, their primary intent is to offer summaries of existing knowledge, and to provide background for some of the active areas which will be discussed in the rest of the meeting.

Multidisciplinary Approach to Optimizing Local Regional Therapy in Hormone Receptor Positive Breast Cancer
Moderator: Armando Giuliano, MD
Cedars-Sinai Medical Center
Los Angeles, CA

Decision making regarding timing of therapy: upfront surgery? Neoadjuvant chemotherapy? Neoadjuvant endocrine therapy?
Otto Metzger, MD
Dana-Farber Cancer Institute,
Boston, MA

Surgical management of the upfront surgery patient
Melissa L. Pilewskie, MD
Memorial Sloan Kettering Cancer Center
New York, NY

Local regional therapy considerations after preoperative therapy in hormone receptor positive breast cancer
Tari Ann King, MD
Dana-Farber Cancer Institute
Brigham and Women's Cancer Center
Boston, MA

Tailoring Adjuvant Therapies Based on Neoadjuvant Response
Moderator: Charles E. Geyer, MD
Virginia Commonwealth University
Massey Cancer Center
Richmond, VA

The biology and plasticity of residual disease
Charles M. Perou, PhD
University of North Carolina
Chapel Hill, NC

Clinical management
Jenny C. Chang, MD
Houston Methodist Hospital
Houston, TX

Locoregional 
Julia White, MD
The Ohio State University
Columbus, OH

Targeted Treatment Beyond PARP1 Inhibition
Moderator: Alexander Bishop, DPhil
Greehey Children's Cancer Research Institute
UT Health San Antonio
San Antonio, TX

Clinical indications of PARP1 inhibitors and other targets
Melinda L. Telli, MD
Stanford University Medical Center
Stanford, CA

Novel DNA repair targets for breast cancer
Thomas Helleday, PhD
University of Sheffield
Sheffield, UNITED KINGDOM

Clinically relevant biomarkers of PARP1 inhibitor resistance and indicators of targeted combinatorial treatments 
Violeta Serra, PhD
Vall d'Hebron Institute of Oncology
Barcelona, SPAIN

Implementation of Genetic Testing in Breast Cancer Patients
Moderator: Virginia G. Kaklamani, MD
UT Health San Antonio
San Antonio, TX

Genetic testing for hereditary breast cancer: Who should be tested?  
Nadine Tung, MD
Beth Israel Deaconess Medical Center
Boston, MA

Approaches to genetic counseling and testing
Banu Arun, MD
University of Texas MD Anderson Cancer Center
Houston, TX

Impact of genetic information for breast cancer patients
Judith Balmaña, MD, PhD
Vall d'Hebron Institute of Oncology
Barcelona, SPAIN

Acquired Endocrine Therapy Resistance Beyond ESR1 Mutations
Moderator: Carlos L. Arteaga, MD
UT Southwestern Medical Center
Simmons Comprehensive Cancer Center
Dallas, TX

Adaptive resistance
Suzanne A.W. Fuqua, PhD
Baylor College of Medicine
Houston, TX

Exploiting single cell transcriptome analyses to track adaptation to endocrine therapies
Luca Magnani, PhD
Imperial College London 
London, UNITED KINGDOM

The genomic landscape of endocrine-resistant metastatic breast cancer
Pedram Razavi, MD, PhD
Memorial Sloan Kettering Cancer Center
New York, NY

Breast Cancer Prevention
Moderator: Judy E. Garber, MD, MPH
Dana-Farber Cancer Institute
Boston, MA

Targeted approach to breast cancer surveillance in high risk women: Update of the newest technologies and how to use them
Maxine S. Jochelson, MD
Memorial Sloan Kettering Cancer Center
New York, NY

Risk-based recommendations: considering the time-frame
Seema A. Khan, MD
Northwestern University
Chicago, IL

Low dose tamoxifen and other approaches to improve chemoprevention uptake  
Andrea DeCensi, MD
E.O. Ospedali Galliera 
Genova, ITALY

Evolving Opportunities to Personalize Radiation Decisions
Moderator: Reshma Jagsi, MD, DPhil
University of Michigan
Ann Arbor, MI

Guiding decisions to omit RT after BCS in DCIS
Eileen Rakovitch, MD, FRCP(C), MSc
Sunnybrook Health Sciences Centre
Toronto, CANADA

Guiding decisions to omit radiation after breast conserving surgery for invasive breast cancer
Corey Speers MD, PhD
University of Michigan
Ann Arbor, MI

Guiding selection of RT approach after lumpectomy
Simona Shaitelman, MD
University of Texas MD Anderson Cancer Center 
Houston, TX

Conversations on Tough Topics Surrounding Cancer Care
Moderator: Susan Rafte
Community Advocate, Baylor College of Medicine Breast Center
Houston, TX

Progression of disease and end of life: How to break bad news
Eric P. Winer, MD
Dana-Farber Cancer Institute
Boston, MA

The toll on health care providers
Sharon H. Giordano, MD, MPH, FASCO
University of Texas MD Anderson Cancer Center
Houston, TX

Financial toxicities
Rachel Greenup, MD, MPH
Duke University School of Medicine
Durham, NC

Panel Discussion

TNBC: Immunotherapy and Beyond
Moderator: Sylvia Adams, MD
NYU Langone Health
New York, NY

Immunotherapy in metastatic and neoadjuvant breast cancer
Rita Nanda, MD
University of Chicago
Chicago, IL

Detecting and managing IO related toxicities wisely
Peter Schmid, MD, PhD
Barts Cancer Institute
London, UNITED KINGDOM

Detect or not detect - the question is PD-L1/PD-1 how, when, why
David L. Rimm, MD, PhD
Yale University School of Medicine
New Haven, CT

Breast Cell Fate Control and Plasticity
Moderator: Yi Li, PhD
Baylor College of Medicine
Houston, TX

Lineage tracing of mammary cells
Cedric Blanpain, MD, PhD
Universite Libre de Bruxelles
Bruxelles, BELGIUM

Cell state plasticity
Geoffrey Wahl, PhD
Salk Institute for Biological Studies
La Jolla, CA

Cell fate plasticity during breast cancer development - where is the translational utility?
Christina Scheel, MD
Helmholtz Center Munich
Institute of Stem Cell Research
Neuherberg, GERMANY

Endocrine Therapy 2020
Moderator: Mothaffar Rimawi, MD
Baylor College of Medicine
Houston, TX

Adjuvant endocrine therapy in 2020: It's complicated
Angelo Di Leo, MD, PhD
Hospital of Prato 
Prato, ITALY

Endocrine therapy beyond 2020 (metastatic, new agents)
Erica L. Mayer, MD, MPH
Dana-Farber Cancer Institute
Harvard Medical School 
Boston, MA

Everything comes with a price (toxicity)
Dawn Hershman, MD
Columbia University Medical Center
New York Presbyterian Hospital
New York, NY 

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William L. McGuire Memorial Lecture

AACR Distinguished Lectureship in Breast Cancer Research

AACR Outstanding Investigator Award for Breast Cancer Research, funded by the Breast Cancer Research Foundation

Susan G. Komen® Brinker Awards

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Advances in Radiation Therapy for Oligometastatic Breast Cancer 
Ralph R. Weichselbaum, MD
University of Chicago
Chicago, IL

The Tumor Microenvironment and Immunosuppression
Ellen Pure, PhD
University of Pennsylvania
Philadelphia, PA

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Future of Immuno-oncology in Breast Cancer
Co-Moderator: Jenny C. Chang, MD
Houston Methodist Hospital
Houston, TX

Co-Moderator: Helen Heslop, MD, DSc
Texas Children's Hospital
Houston, TX

Immunotherapy in breast cancer: enhancing response to checkpoint blockade
Elizabeth A. Mittendorf, MD, PhD
Dana-Farber Cancer Institute
Brigham and Women's Cancer Center
Boston, MA

Engineering next-gen T cell based immunotherapies for breast cancer
Christopher A. Klebanoff, MD
Memorial Sloan Kettering Cancer Center
New York, NY

Targeting the Cell Cycle Kinase CDK 4/6 and Beyond
Moderator: Angela DeMichele, MD, MSCE
Abramson Cancer Center
University of Pennsylvania
Philadelphia, PA

Mechanisms of resistance to CDK4/6 inhibitors and new therapeutic approaches
Sarat Chandarlapaty, MD, PhD
Memorial Sloan Kettering Cancer Center
New York, NY

Targeting the cell cycle - Beyond CDK4/6 inhibition
Rinath Jeselsohn, MD
Dana-Farber Cancer Institute
Boston, MA

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Saturday, December 14, 2019

Moderator: C. Kent Osborne, MD
Baylor College of Medicine
Dan L. Duncan Comprehensive Cancer Center
Houston, TX

Basic science
Alana L. Welm, PhD
University of Utah
Huntsman Cancer Institute
Salt Lake City, UT

Translational research
Geoffrey Lindeman, MD, PhD
The Walter & Eliza Hall Institute of Medical Research
Parkville, AUSTRALIA

Early breast cancer   
Masakazu Toi, MD, PhD
Kyoto University
Kyoto, JAPAN

Metastatic breast cancer
Sara Hurvitz, MD
University of California Los Angeles
Los Angeles, CA

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RNA Rewiring in Breast Cancer Progression
Moderator: Chonghui Cheng, MD, PhD
Baylor College of Medicine
Houston, TX

Comprehensive analysis of alternative splicing in patient breast tumors
Howard Chang, MD, PhD
Stanford University
Stanford, CA

RNA methylation in cancer progression
Chuan He, PhD
University of Chicago 
Chicago, IL

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The Communal Road to Metastasis: CTC Clusters
Moderator: Rachel Schiff, PhD
Baylor College of Medicine
Lester & Sue Smith Breast Center
Houston, TX

CTC clusters, cancer stemness, and new treatment strategies 
Huiping Liu, MD, PhD
Northwestern University
Chicago, IL

Biology, vulnerabilities and clinical implications of CTC clusters
Nicola Aceto, PhD
University of Basel
Basel, SWITZERLAND

Proteogenomics of Breast Cancer, From Discovery to Precision Medicine
Moderator: Matthew J. Ellis, MB, BChir, BSc., PhD, FRCP
Baylor College of Medicine
Lester & Sue Smith Breast Center
Houston, TX

    Advanced enabling technologies for cancer proteomics
            Tao Liu, PhD
    Pacific Northwest National Laboratory
            Richland, WA

Clinical proteomics tumor analysis consortium breast cancer marker studies 
Michael Gillette, MD, PhD
Broad Institute
Cambridge, MA 

Proteogenomics and clinical translation
Matthew J. Ellis, MB, BChir, BSc., PhD, FRCP
Baylor College of Medicine
Houston, TX

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Frontiers in HER2 Positive Breast Cancer
Moderator: Sibylle Loibl MD
German Breast Group
University of Frankfurt
Neu-Isenburg, GERMANY

Heterogeneity of HER2+ breast cancer
Andrea L. Richardson, MD, PhD
Johns Hopkins Medicine
Baltimore, MD

New agents for HER2+ treatment
Shanu Modi, MD
Memorial Sloan Kettering Cancer Center
New York, NY

Brain metastases - clinical dilemmas and scientific challenges
Nancy U. Lin, MD
Dana-Farber Cancer Institute
Boston, MA

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Molecular Biology in Breast Oncology
Moderator: Carlos L. Arteaga, MD
UT Southwestern Medical Center
Simmons Comprehensive Cancer Center
Dallas, TX

Functional genomics
TBA

Imaging using computational methods
TBA

The science behind antibody drug conjugates
TBA

Developing Novel Therapeutics in the Metastatic Setting
Moderator: Virginia G. Kaklamani, MD
UT Health San Antonio
San Antonio, TX

Writing a clinical trial - window vs neoadjuvant trial
Alastair M. Thompson, ALCM, BSc(Hons), MBChB, MD, FRCSEd(Gen)
Baylor College of Medicine
Houston, TX

Therapeutic development in the era of precision medicine: Paradigm shift from maximum tolerated dose (MTD) to optimal biological dose (OBD)
Aditya Bardia, MD, MPH
Massachusetts General Hospital
Harvard Medical School
Boston, MA

Design and analysis of window and neoadjuvant trials
Meredith Regan, ScD
Dana-Farber Cancer Institute
Harvard Medical School
Boston, MA

How to talk to patients about participating in clinical trials
Patty Spears, BSc
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, NC

 

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Moderator: Mothaffar Rimawi, MD
Baylor College of Medicine
Houston, TX                                                                                                                           



CAREER DEVELOPMENT FORUMNETWORKING SESSION FOR YOUNG INVESTIGATORS

                                                                                                                       

The session is open to early-career scientists, defined as graduate students, postdoctoral or clinical fellows, or medical students and residents, who are registered attendees of the 2019 SABCS. Space in the workshop is limited. Preregistration is not required.                                                                                                                             




  

Mastectomy should not be offered to patients who are breast conservation candidates when modern radiotherapy is available
Chairman: Richard Crownover, MD, PhD
UT Health San Antonio
San Antonio, TX



Friday, December 13, 2019: 


        Moderator: Ruth O'Regan, MD
        University of Wisconsin
        Carbone Cancer Center
        Madison, WI

        Panel Members

        Joseph Sparano, MD
        Montefiore Medical Center
        Albert Einstein College of Medicine
        Bronx, NY

        Debra A. Patt, MD, MPH
        Texas Oncology
        Austin, TX

        Nadia Harbeck, MD, PhD
        Ludwig Maximilian University of Munich
        Munich, GERMANY

        Barbara Segarra Vázquez, MT, DHSc
        University of Puerto Rico
        San Juan, PR

        E. Shelley Hwang, MD, MPH
        Duke University
        Durham, NC Top


PRELIMINARY SCHEDULE


Hours subject to change



 

Monday, December 9  Registration  12:00 PM - 5:00 PM 
Tuesday, December 10  Registration  8:00 AM - 7:00 PM ;
  Program (Workshops and Educational Sessions)  11:00 AM - 7:00 PM 
Wednesday, December 11  Registration  7:00 AM - 5:15 PM 
  Program (Main Program begins)  8:00 AM - 7:00 PM 
  Exhibits  11:00 AM - 5:00 PM 
Thursday, December 12  Registration  6:45 AM - 5:15 PM 
  Program  7:00 AM - 7:00 PM 
  Exhibits  11:00 AM - 5:00 PM 
Friday, December 13  Registration  6:45 AM - 5:15 PM 
  Program  7:00 AM - 7:30 PM 
  Exhibits  11:00 AM - 5:00 PM 
Saturday, December 14  Registration  6:45 AM - 9:00 AM 
  Program  7:00 AM - 11:00 AM 

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